Blast crisis in chronic myeloid leukemia: An immunophenotypic analysis

Background and Aim of Study: There are two different phases untreated chronic myeloid leukemia – phase, blast crisis according to the World Health Organization classification Hematolymphoid tumors. The cells in can express myeloid, lymphoid, bi-phenotypic, monocytic, megakaryocytic, erythroid phenotypes. immunophenotype population determines how patients respond treatment, hence flowcytometric examination is required. aim study: assess immunophenotyping outcomes flowcytometry performed on crisis. Material Methods: A five-year retrospective descriptive analysis was carried out Pathology Department at King George’s Medical University Lucknow, India (2017-2021). patient’s peripheral blood bone marrow aspirate samples were analyzed. Clinical, hematological, immunophenotypic data retrieved. flow cytometry prepared using standardized “lyse-stain-wash” method. Results: total 43 cases retrieved from departmental archive 5 years. mean age study 39.62±14.86 24 males 19 females. 27 diagnosed with crisis, 14 B-lymphoid 2 mixed phenotypic acute leukemia. Conclusions: Identification lineage crucial since existence atypical phenotypes influences disease treatment prognosis.